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TheScientificWorldJOURNAL
Volume 1 (2001), Pages 34-34
http://dx.doi.org/10.1100/tsw.2001.406
Extended Abstract

EFFECT OF CGRP AND RELATED PEPTIDES IN THE MICROCIRCULATION

Copyright © 2001 S.D. Brain and D.Q. Chu.

Abstract

We are interested in the potential of CGRP and adrenomedullin (ADM) as proinflammatory peptides and have compared the ability of CGRP and ADM to modulate microvascular and nociceptive (thermal hyperalgesic) responses in rat skin. Vasodilator activity was assessed by laser Doppler flowmetry, inflammatory oedema by the extravascular accumulation of i.v.-injected radiolabelled albumin, and neutrophil accumulation by tissue myeloperoxidase. Hyperalgesia was assessed by a thermal hyperalgesimeter in paw skin.