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TheScientificWorldJOURNAL
Volume 2 (2002), Pages 1186-1195
http://dx.doi.org/10.1100/tsw.2002.214
Review Article

Regulation of Apoptosis in African Swine Fever Virus–Infected Macrophages

Plum Island Animal Disease Center, USDA, ARS, P.O.Box 848, Greenport, NY 11944, USA

Copyright © 2002 Laslo Zsak and John G. Neilan.

Abstract

A number of viruses have evolved antiapoptotic mechanisms to promote infected-cell survival, either to ensure efficient productive viral replication or to promote long-term survival of virus-infected cells. Recent studies identified critical African swine fever virus genes involved in the complex regulation of ASFV-host interactions. Here we review the present knowledge of the recently identified ASFV genes with special attention to those which affect viral virulence, host range, and pathogenesis by regulating viral-induced apoptotic mechanisms.