Journal Menu
- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Submit a Manuscript
- Subscription Information
- Table of Contents
TheScientificWorldJOURNAL
Volume 3 (2003), Pages 677-683
doi:10.1100/tsw.2003.53
Mini-Review Article
Volume Transmission and Pain Perception
Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, México, D.F. 07300, Mexico.
Academic Editor: Luigi Francesco Agnati
Copyright © 2003 Gilberto C. Castaneda-Hernandez1 and Paul Bach-y-Rita.
Abstract
Volume transmission (VT) is the diffusion through the brain extracellular fluid of neurotransmitters released at points that may be remote from the target cells with the resulting activation of extrasynaptic receptors. VT appears to play multiple roles in the brain in normal and abnormal activity, brain plasticity and drug actions. The relevance of VT to pain perception has been explored in this review.