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TheScientificWorldJOURNAL
Volume 5 (2005), Pages 661-664
http://dx.doi.org/10.1100/tsw.2005.87
Short Communication

Ovarian Abnormalities in the Staggerer Mutant Mouse

1Laboratoire d'Ethologie et de Sociobiologie, Université de Paris XIII, Paris, France
2Service des Relations Internationales, Université Henri Poincaré-Nancy I, 24-30 rue Lionnois, BP 60120, 54003 Nancy Cedex, France
3Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Avenue des Facultés, 33405 Talence, France

Received 2 June 2005; Revised 14 August 2005; Accepted 16 August 2005

Copyright © 2005 Jean-Marie Guastavino et al.

Abstract

Disturbances in several reproductive functions of the staggerer cerebellar mutant mouse have been observed. In this study, reproductive efficiency of staggerer mice was compared to normal mice by recording the number of pups produced and the number of oocytes occurring. It was found that staggerer mothers produced smaller litters than controls and the number of oocytes produced in their ovaries was reduced by the staggerer mutation. These results indicate a pleiotropic effect on fertility of the Rorasg gene underlying the cerebellar abnormalities of the staggerer mutant.