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TheScientificWorldJOURNAL
Volume 5 (2005), Pages 609-628
http://dx.doi.org/10.1100/tsw.2005.80
Review Article

Plants and Fungal Products with Activity Against Tuberculosis

FioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-25650, Rio de Janeiro, RJ, Brazil

Received 29 June 2005; Accepted 28 July 2005

Copyright © 2005 Marcus Vinicius Nora De Souza.

Abstract

Tuberculosis (TB) is becoming an ever more serious worldwide problem. This contagious disease kills four people every minute somewhere in the world and accounts for more than 2 million deaths per year. Due to the rapid spread of TB strains resistant to all the major anti-TB drugs on the market, and the association of TB with human immunodeficiency virus (HIV) infection in AIDS, we urgently need to develop new drugs to fight against TB. In this context, due to the importance of nature in the development of new drugs, the aim of the present review is to highlight a series of new and promising anti-TB agents derived from plants and fungi discovered between 2001 and 2005.