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TheScientificWorldJOURNAL
Volume 6 (2006), Pages 502-511
http://dx.doi.org/10.1100/tsw.2006.109
Review Article

Gene Array Studies in Renal Neoplasia

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA

Received 20 January 2006; Revised 19 April 2006; Accepted 20 April 2006

Academic Editor: Daniel Batlle

Copyright © 2006 T. Higgins.

Abstract

Renal cell carcinoma (RCC) is comprised of several distinct histologic subtypes many of which have characteristic cytogenetic abnormalities. The molecular pathogenesis of some of these neoplasms is beginning to be elucidated. Yet renal cell carcinoma is often discovered at an advanced clinical stage and effective pharmacologic therapies for this disease remain to be discovered. For these reasons, renal cell carcinoma is ideally suited to the genome scale investigation made possible by DNA microarrays. A number of DNA array studies of renal cell carcinoma have been published. Renal cell carcinomas have also been studied by array based comparative genomic hybridization. The purpose of this review will be to summarize these studies, to compare the results of the different studies, and to suggest future areas of investigation with a particular emphasis on clinically relevant advances.