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TheScientificWorldJOURNAL
Volume 7 (2007), Pages 204-223
http://dx.doi.org/10.1100/tsw.2007.48
Review Article

From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

Vulnérabilité, Adaptation et Psychopathologie, CNRS UMR 7593, Hôpital Pitié-Salpêtrière, 91 Bd de l'Hôpital, 75634 Paris cedex 13, France

Received 29 August 2006; Revised 6 January 2007; Accepted 18 January 2007

Academic Editor: Wim E. Crusio

Copyright © 2007 Patrice Venault and Georges Chapouthier.

Abstract

A number of beta-carbolines are inverse agonists of the GABA-A receptor complex, acting on the benzodiazepine site. They show convulsive properties when administered at high doses, anxiogenic properties at moderate doses, and learning-enhancing effects at low doses. These data suggest a possible physiological relationship, through the GABA-A receptor channel, between memory processes, anxiety, and ultimately, in pathological states, epileptic seizures. This relationship seems to be confirmed partially by experiments on mouse strains selected for their resistance (BR) and sensitivity (BS) to a single convulsive dose of a beta-carboline. These two strains also show differences in anxiety and learning abilities. However, some opposite results found while observing the behavior of the two strains suggest that in addition to pharmacologically induced anxiety, there is spontaneous anxiety, no doubt involving other brain mechanisms.