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TheScientificWorldJOURNAL
Volume 9 (2009), Pages 1300-1305
doi:10.1100/tsw.2009.146
Botulinum Toxin-A Therapy in Pediatric Urology: Indications for the Neurogenic and Non-Neurogenic Neurogenic Bladder
Department of Pediatric Urology, New York Medical College, Valhalla, USA
Academic Editor: Barry Duel
Copyright © 2009 Lori Dyer and Israel Franco.
Abstract
Although, the role of Botulinum Toxin-A in the treatment of the neurogenic and non-neurogenic neurogenic bladder is becoming more defined, this is the first review article to characterize the emerging role of Botulinum Toxin-A in the pediatric urologic population. Injection of Botulinum Toxin-A at the level of the bladder works by inhibiting uninhibited bladder contractions and, possibly, by blocking some of the sensory nerve fibers. In children with sphincter dyssynergy, injection at the level of the urethral sphincter works by inhibiting the involuntary guarding reflex and blocking dyssynergic voiding.