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TheScientificWorldJOURNAL
Volume 9 (2009), Pages 1300-1305
http://dx.doi.org/10.1100/tsw.2009.146
Review Article

Botulinum Toxin-A Therapy in Pediatric Urology: Indications for the Neurogenic and Non-Neurogenic Neurogenic Bladder

Department of Pediatric Urology, New York Medical College, Valhalla, USA

Academic Editor: Barry Duel

Copyright © 2009 Lori Dyer and Israel Franco.

Abstract

Although, the role of Botulinum Toxin-A in the treatment of the neurogenic and non-neurogenic neurogenic bladder is becoming more defined, this is the first review article to characterize the emerging role of Botulinum Toxin-A in the pediatric urologic population. Injection of Botulinum Toxin-A at the level of the bladder works by inhibiting uninhibited bladder contractions and, possibly, by blocking some of the sensory nerve fibers. In children with sphincter dyssynergy, injection at the level of the urethral sphincter works by inhibiting the involuntary guarding reflex and blocking dyssynergic voiding.