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TheScientificWorldJOURNAL
Volume 9 (2009), Pages 940-945
http://dx.doi.org/10.1100/tsw.2009.110
Case Study

Castleman's Disease: An Intrapulmonary Form with Intrafissural Development

1Pulmonology Department, Pavillon II, Abderrahman Mami Hospital, Ariana, Tunisia
2Pathology Department, Abderrahman Mami Hospital, Ariana, Tunisia
3Radiology Department, Abderrahman Mami Hospital, Ariana, Tunisia
4Thoracic Surgery Department, Abderrahman Mami Hospital, Ariana, Tunisia

Received 29 April 2009; Revised 1 September 2009; Accepted 1 September 2009

Academic Editor: Klaus Kayser

Copyright © 2009 Hajer Racil et al.

Abstract

Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea and nonproductive cough, whose chest X-ray showed an abnormal shadow of the right hilum. Chest computed tomography confirmed the presence of a tissue-density mass of the right lower lobe, demonstrating poor contrast enhancement, associated with multiple laterotracheal and mediastinal lymphadenopathies. The patient underwent curative surgery, revealing a right hilar compressive mass, with an intrafissural development between the superior and middle lobes. Pneumonectomy was performed due to profuse bleeding. This case of CD is particular because of its unusual intrapulmonary location and its intrafissural development. Poor contrast enhancement is atypical in CD.