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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 1731-1748
http://dx.doi.org/10.1100/tsw.2010.169
Mini-Review Article

Role of Neutrophil Apoptosis in the Resolution of Inflammation

Research Center Maisonneuve-Rosemont Hospital, Department of Pathology and Cell Biology, University of Montreal, QC, Canada

Received 26 June 2010; Revised 2 August 2010; Accepted 3 August 2010

Academic Editor: Charles N. Serhan

Copyright © 2010 Driss El Kebir and János G. Filep. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neutrophil granulocytes play a central role in host defense to infection and tissue injury. Their timely removal is essential for resolution of inflammation. Increasing evidence identified neutrophil apoptosis as an important control point in the development and resolution of inflammation. Delayed apoptosis and/or impaired clearance of neutrophils aggravate and prolong tissue injury. This review will focus on outside-in signals that provide survival cues for neutrophils, the hierarchy of pro- and antiapoptotic signals, and molecular targets in the antiapoptotic signaling network that can be exploited by endogenously produced bioactive lipids, such as lipoxins or pharmacological inhibitors, including cyclin-dependent kinase inhibitors, to redirect neutrophils to apoptosis in vivo, thus promoting resolution of inflammation.