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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 457-461
doi:10.1100/tsw.2010.49
Mini-Review Article
Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
National Brain Research Centre, Manesar, Haryana-122050, India
Received 13 October 2009; Revised 27 February 2010; Accepted 1 March 2010
Academic Editor: Rudy Tanzi
Copyright © 2010 Shiv K. Sharma.
Abstract
The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. HGF signaling, which is initiated by its binding to a receptor tyrosine kinase, plays critical roles during development. HGF and its receptor are also present in brain cells. This review describes the role of HGF in hippocampal neurons, synaptic plasticity, and the memory impairment condition, Alzheimer's disease.