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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 2248-2253
http://dx.doi.org/10.1100/tsw.2010.207
Mini-Review Article

New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway

1Department of Orthopaedics, Second Clinical Medical College, Jinan University, Shenzhen, Guangdong Province, China
2Department of Orthopaedics, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
3Department of Orthopaedics, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
4Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China
5Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong SAR, China
6Department of Orthopaedics, Taian Hospital of Traditional Chinese Medicine, Taian, Shandong Province, China

Received 13 August 2010; Revised 23 September 2010; Accepted 11 October 2010

Academic Editor: John L. Wallace

Copyright © 2010 Xiao Hua Pan et al.

Abstract

Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). New drug discovery and development via the recently discovered cholinergic anti-inflammatory and antinociceptive pathways should be promising. Based on the above, the nicotinic acetylcholine receptor agonists maintain the potential for the treatment of RA. Therefore, new therapeutic approaches may rise from these two newly discovered pathways. More preclinical experiments and clinical trials are required to confirm our viewpoint.