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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 1947-1957
http://dx.doi.org/10.1100/tsw.2010.183
Review Article

Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

1INSERM U624, “Cell Stress” Biology of Pancreas Stress Laboratory, Marseille, France
2Department of Medical Oncology, Kanazawa Medical University, Ishikawa, Japan

Received 21 July 2010; Revised 7 September 2010; Accepted 8 September 2010

Academic Editors: Juan Iovanna and José Neira

Copyright © 2010 Carla E. Cano et al.

Abstract

Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/aggressiveness, and the drug resistance of pancreatic cancer cells.