New Role for L-Arginine in Regulation of Inducible Nitric-Oxide-Synthase-Derived Superoxide Anion Production in Raw 264.7 Macrophages
Figure 5
NOS inhibitors-dependent regulation of LPS-induced nitrite accumulation and production in RAW 264.7 cells stimulated by LPS. Cells were pretreated with NOS inhibitors at the indicated concentrations in the presence of DMEM media containing 400 μM of L-arginine. (a) The LPS-induced iNOS protein expression and nitrite accumulation were determined after 24 h of cell incubation (). (b) The production was measured in the presence of DMEM media containing 400 μM of L-arginine in two time points: 10 and 15 h after LPS administration (). .
