Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma

Table 2

HLA class I and II alleles and haplotypes and their associations with overall survival among diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) patients.

		DLBCL			FL
Allele/Haplotype	Status	Total no.	No. of deaths	HR (95%CI)	Total no.	No. of deaths	HR (95%CI)
HLA class I
HLA-A*01:01	Absent	107	31	1.00 (ref)	109	23	1.00 (ref)
	Present	59	21	1.30 (0.74–2.26)	54	22	2.23 (1.24–4.01)
HLA-B*08:01	Absent	123	35	1.00 (ref)	123	32	1.0 (ref)
	Present	42	17	1.40 (0.78–2.51)	42	14	1.39 (0.74–2.61)
HLA-Cw*07:01	Absent	111	28	1.00 (ref)	116	32	1.00 (ref)
	Present	55	24	1.76 (1.01–3.05)	49	14	1.12 (0.60–2.10)
HLA-B Bw4	Absent	73	27	1.00 (ref)	55	25	1.00 (ref)
	Present	106	31	0.97 (0.58–1.64)	125	23	0.36 (0.20–0.63)
HLA class II
HLA-DRB1*01:01	Absent	134	43	1.00 (ref)	118	32	1.00 (ref)
	Present	32	9	0.94 (0.46–1.94)	47	14	1.12 (0.59–2.10)
HLA-DRB1*03:01	Absent	121	34	1.00 (ref)	127	33	1.00 (ref)
	Present	45	18	1.41 (0.79–2.50)	38	13	1.33 (0.70–2.54)
HLA-DRB1*13	Absent	137	39	1.00 (ref)	146	47	1.00 (ref)
	Present	29	13	1.34 (0.71–2.55)	19	1	0.12 (0.02–0.90)
AH 8.1
HLA-A*01-B*08-DR*03	Absent	135	40	1.00 (ref)	143	35	1.00 (ref)
	Present	30	12	1.46 (0.76–2.80)	20	10	2.19 (1.08–4.45)
TNF G-308A	GG	98	26	1.00 (ref)	107	28	1.00 (ref)
	GA	53	21	1.66 (0.93–2.97)	42	15	1.52 (0.81–2.86)
	AA	6	3	3.81 (1.13–12.9)	4	1	0.84 (0.11–6.19)
	GA/AA	59	24	1.79 (1.02–3.14)	46	16	1.45 (0.78–2.68)
HLA-A*01-B*08-DR*03-TNF-A	Absent	132	39	1.00 (ref)	135	34	1.00 (ref)
	Present	29	11	1.39 (0.71–2.73)	20	10	2.13 (1.05–4.34)

All models adjusted for the risk score that combined both demographic and clinical information.
The total numbers for each allele may differ due to laboratory interpretation of each allele which was done individually (e.g., ambiguous results for each allele were excluded from analysis rather than presumed to be absent).