(a) Phase contrast micrograph illustrating the arrangement of human endothelial cells (HUVECs) into a meshwork of capillary-like tubular structures when cultured on Matrigel for 18 hr. (b) Typical patterns generated by a CPM tuned to simulate the in vitro organization of the cells after 18 hr of culture. (c) Number of branching points over time (see [57, 59]) for in vitro and in silico capillary-like patterns illustrating that the time course of pattern formation by HUVEC is well captured by the model.
