Review Article

Embryonic Regulation of the Mouse Hematopoietic Niche

Figure 1

Schema of hematopoietic development during mouse embryogenesis. (a) The site of blood cell production changes as embryos develop over an approximately 20-day gestation period in mice. Abbreviations: dpc (day post coitum), YS (yolk sac), BI (blood island), AGM (aorta-gonad-mesonephros), PL (placenta), FL (fetal liver), BM (bone marrow), HSC (hematopoietic stem cell). (b) Corresponding to the time course shown in (a), HSCs emerge in the YS, AGM region, and PL from early to mid-gestation (7.0–11.0 dpc). HSCs proliferate in the FL at mid-gestation and then home to fetal spleen temporarily and to fetal BM at late gestation.
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(a)
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(b)