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TheScientificWorldJOURNAL
Volume 11 (2011), Pages 235-241
http://dx.doi.org/10.1100/tsw.2011.15
Hypothesis

Lipoxins: A Novel Regulator in Embryo Implantation

1Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Received 20 October 2010; Revised 1 December 2010; Accepted 9 December 2010

Academic Editor: Joan Clària

Copyright © 2011 Xiong Jing et al.

Abstract

Embryo implantation is essential for mammalian pregnancy, which involves intricate cross-talk between the blastocyst and the maternal endometrium. Recent advances have identified various molecules crucial to implantation and endometrial receptivity, including leukemia inhibitory factor, calcitonin, and homeobox A10. There is a close relationship between implantation and inflammation. Lipoxins, important in the resolution of inflammation, may be a potential regulator in implantation. Here we discuss the hypothesis that lipoxins may work as a novel regulator in embryo implantation and the possible molecular mechanisms.