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TheScientificWorldJOURNAL
Volume 11 (2011), Pages 826-841
http://dx.doi.org/10.1100/tsw.2011.86
Review Article

Epithelial Tight Junctional Changes in Colorectal Cancer Tissues

1Lankenau Institute for Medical Research, Wynnewood, PA, USA
2Division of Gastroenterology, Lankenau Medical Center, Wynnewood, PA, USA

Received 5 May 2010; Revised 15 March 2011; Accepted 17 March 2011

Academic Editor: Kim Barrett

Copyright © 2011 Xuexuan Wang et al.

Abstract

Colorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce mortality. Tight junctions (TJ) are well known for their function in controlling paracellular traffic of ions and molecules. It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. This review will present recent data from clinical and animal studies showing how altered TJ protein expression is a feature of certain CRCs. The up-regulation of claudin-1 in many CRCs is especially noteworthy. The focus of this article is simply on the association – however imperfect – between CRC and the major TJ transmembrane barrier proteins, namely claudins and occludin. Any causal relationship between TJ protein change and neoplasia remains conclusively unproven at present.