Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions

Table 2

Type II and I IFN additive, opposite and counter-regulatory effects on dendritic cells. The scheme depicted resumes the most important overlapping, additive, opposite and counter-regulatory effects of type II and I IFNs on DCs. Numbers refer to references reported in the References section.

IFN-γ		IFN-α/β
Potentiates for cancer therapy [23, 24, 37]	+	Potentiate for cancer therapy [23, 24, 37]
Diminishes IL-10 and STAT3, by DCs [16]	≠	Increase IL-10 production, by DCs [72, 73]
Inhibits IL-1β production by mouse DC and increases IL-1β in human DCs [74, 75]	≠	Inhibit IL-1β production by both mouseand human DCs [74, 75]
Regulate response to itself [76, 77]		Regulate response to themselves [78]
IFN-γ effects counteracted by IFN-α/β [31, 79]		Inhibit IL-12p70 production by mature DCs and IFN-γ effects on DCs irrespective of thier maturation status [31, 79, 80]
Response to IFN-γ regulated by type I IFN both in vitro [31, 79, 80] and in vitro [81–83]		Inhibit IFN-γ production in vivo by down regulation of IFN-γ receptor [84, 85] or up-regulation SOSCS1 [83] in DCs

+ Additive, ≠ opposing, counterregulatory, effects on DCs.