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TheScientificWorldJOURNAL
Volume 11 (2011), Pages 1582-1590
doi:10.1100/tsw.2011.147
Comparison between Carotid Artery Wall Thickness Measured by Multidetector Row Computed Tomography Angiography and Intimae-Media Thickness Measured by Sonography
1Center of Radiology and Magnetic Resonance, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbia
2Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Serbia
3Clinical Center Zvezdara, Department of Cardiology, Belgrade, Serbia
4Clinic for Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbia
5Institute of Pathophysiology, Faculty of Medicine, University of Belgrade, Serbia
6Clinic for Lung Diseases, Clinical Center of Serbia, Belgrade, Medical School, University of Belgrade, Serbia
Received 7 May 2011; Revised 31 July 2011; Accepted 6 August 2011
Academic Editor: Bernhard Schaller
Copyright © 2011 Živorad N. Savić et al.
Abstract
The increased thickness of the carotid wall >1 mm is a significant predictor of coronary and cerebrovascular diseases. The purpose of our study was to assess the agreement between multidetector row computed tomography angiography (MDCTA) in measuring carotid artery wall thickness (CAWT) and color Doppler ultrasound (CD-US) in measuring intimae-media thickness (IMT). Eighty-nine patients (aged 35–81) were prospectively analyzed using a 64-detector MDCTA and a CD-US scanner. Continuous data were described as the mean value ± standard deviation, and were compared using the Mann–Whitney U test. A p value <0.05 was considered significant. Bland–Altman statistics were employed to measure the agreement between MDCTA and CD-US. CAWT ranged from 0.62 to 1.60 mm, with a mean value of 1.09 mm. IMT ranged from 0.60 to 1.55 mm, with a mean value of 1.06 mm. We observed an excellent agreement between CD-US and MDCTA in the evaluation of the common carotid artery thickness, with a bias between methods of 0.029 mm (which is a highly statistically important difference of absolute values [t = 43.289; p < 0.01] obtained by paired T test), and limits of agreement from 0.04 to 0.104. Pearson correlation coefficient was 0.9997 (95% CI 0.9996–0.9998; p < 0.01). We conclude that there is an excellent correlation between CAWT and IMT measurements obtained with the MDCTA and CD-US.