Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7

Table 1

Synthesis of Compound 1 at room temperature in the presence of PPA and Lithium-acetate in different solvents.^a

Entry	Solvent	Catalyst	Time (hrs)	Yield (%)
1	EtOH	PPA	4	67
2	CH3CN	PPA	5	58
3	THF	PPA	2	73
4	Toluene	PPA	8	48
5	EtOH	Lithium-Acetate	4	63
6	CH3CN	Lithium-Acetate	3	73
7	THF	Lithium-Acetate	6	68
8	Toluene	Lithium-Acetate	7	43

^aThe reactions were carried out in the presence of benzaldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), urea (2.0 mmol), and PPA or lithium-acetate (0.5 mmol) at room temperature for 6-7 hrs.