The Scientific World Journal

Research Article

Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7

Table 3

(a) Invitro cytotoxic effects of DHPMs against human lung cancer cell line A549.


		Human lung cancer cell line A549
		% Control growth
		Molar drug concentrations
Codes	Compound	Experiment 1				Experiment 2				Experiment 3				Average Values
		10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M

B-06	06	98.2	95.8	91.7	71.6	99.1	91.6	90.0	58.0	100.6	95.2	89.2	66.8	99.3	94.2	90.3	65.5
B-07	16	100.0	100.0	100.0	72.6	100.0	100.0	97.0	71.6	100.0	100.0	97.4	75.0	100.0	100.0	98.1	73.1
B-08	18	100.0	100.0	99.6	74.8	100.0	97.2	97.3	69.6	100.0	99.4	97.7	67.6	100.0	98.9	98.2	70.7
B-09	23	100.0	100.0	100.0	63.3	100.0	93.9	93.1	62.2	96.3	94.8	83.5	63.4	98.8	96.2	92.2	62.9
B-10	24	97.3	96.7	95.3	68.5	100.0	96.4	86.5	64.3	100.0	100.0	94.8	71.5	99.1	97.7	92.2	68.1
ADR	ADR	18.5	7.6	4.5	3.8	32.4	6.5	8.5	−10.2	24.8	15.8	10.6	0.1	25.2	10.0	7.9	−2.1

(b)


Compound	A549
	LC50	TGI	GI50*

06	>100	>100	>100
16	>100	>100	>100
18	>100	>100	>100
23	>100	>100	>100
24	>100	>100	>100
ADR	>100	85.94	<0.1

*GI50 ≤1 μMolar is considered to be active.