The Scientific World Journal

Research Article

Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7

Table 4

(a) Invitro cytotoxic effects of DHPMs against human breast cancer cell line MCF7.


		Human breast cancer cell line MCF7
		% Control growth
		Molar drug concentrations
Codes	Compound	Experiment 1				Experiment 2				Experiment 3				Average Values
		10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M	10⁻⁷M	10⁻⁶M	10⁻⁵M	10⁻⁴M

B-01	02	100.0	89.2	62.2	34.6	100.0	94.4	71.8	30.1	100.0	92.4	70.3	40.3	100.0	92.0	68.1	35.0
B-02	03	100.0	97.6	83.4	70.6	100.0	95.9	93.4	84.1	100.0	96.5	94.6	83.0	100.0	96.7	90.5	79.2
B-03	07	97.5	71.7	31.7	−14.0	100.0	85.2	38.6	−10.0	77.3	74.4	44.1	8.5	91.6	77.1	38.2	−5.2
B-04	12	100.0	99.2	88.5	79.8	100.0	99.8	89.3	86.7	100.0	100.0	96.2	90.3	100.0	99.7	91.3	85.6
B-05	22	100.0	100.0	89.3	68.9	100.0	99.1	91.1	77.0	100.0	100.0	94.9	80.1	100.0	99.7	91.8	75.3
ADR	ADR	−15.3	−43.9	−65.8	−65.0	−5.0	−33.0	−57.4	−61.6	−14.9	−33.4	−55.7	−57.3	−11.7	−36.8	−59.6	−61.3

(b)


Compound	MCF7
	LC50	TGI	GI50*

02	>100	>100	71.4
03	>100	>100	>100
07	>100	91.3	29.3
12	>100	>100	81.3
22	>100	>100	>100
ADR	54.8	<0.1	<0.1

*GI50 ≤1 μMolar is considered to be active.