Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol

Table 1

Gel temperature of Pluronic F127 and P123 systems solely or containing 5% (w/v) RMβCD and 20% (v/v) ethanol: mean values and, in parenthesis, the standard deviations.

Pluronic %		Without drug or additives	+ βLAP	+ βLAP+ ethanol	+ βLAP+ RMβCD
F127	18%	25.5°C (0.0)	24.1°C (0.6)	6.0°C (2.0)	29.1°C (0.7)
	23%	19.0°C (0.0)	18.9°C (0.6)	11.2°C (0.7)	23.7°C (0.6)
	28%	11.6°C (0.6)	12.8°C (0.6)	—	15.7°C (0.8)
P123	28%	18.9°C (0.5)	18.8°C (0.7)	9.6°C (0.8)	25.0°C (0.8)