Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol

Table 4

Data from fitting βLAP release profiles to zero-order kinetics and total amount of drug released at the end of the assay (D₂₀).

Pluronic %	Additive	Correlation coefficient	Slope (μg h·cm^−2)	D20(μg·cm^−2)
F127 18%	Without	0.999	1.21	37.9
	5% (w/v) RMβCD	0.999	2.19	69.2
F127 23%	Without	0.985	0.30	9.7
	20% (v/v) EtOH	0.967	0.46	14.9
	5% (w/v) RMβCD	0.996	0.94	29.2
F127 28%	Without	0.993	0.31	9.9
	5% (w/v) RMβCD	0.987	0.68	22.1
P123 28%	Without	0.999	0.61	18.8
	20% (v/v) EtOH	0.994	0.70	22.1
	5% (w/v) RMβCD	0.986	1.04	32.8