Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity: Effects of Cadmium, Mercury, and Copper

Table 4

Action of different respiratory chain effectors on viability of PC12 cell assessed by LDH release after different time of incubation with different concentration of Cd²⁺.

Treatment (1 μM)	Control cells (3, 5, 24 h)	500 μM Cd^2+ (3 h)	100 μM Cd^2+ (5 h)	100 μM Cd^2+ (24 h)
Control	100	55±3 *	74±4 *	61±5 *
FCCP	96±2	62±10	89±4 **	75±10
Rotenone	94±1	59±10	84±8	73±7
Myxothiazol	95±1	52±16	85±7	71±5
Antimycin A	96±2	48±14	82±7	72±6
Stigmatellin	99±2	78±5 **	90±5 **	76±1 **

The cell viability is expressed in % to untreated control. Mean ± SE; 𝑛=3–11 independent experiments; *𝑃<0.05 compared to untreated control; **𝑃<0.05 compared to Cd(II)-treated control.