Combined Contribution of Endothelial Relaxing Autacoides in the Rat Femoral Artery Response to CPCA: An Adenosine A₂ Receptor Agonist

Table 1

CPCA-induced relaxation in isolated rat femoral artery in the absence or in the presence of the specific pharmacological intervention. Concentration of CPCA eliciting 50% of its own maximum response (EC₅₀) is presented as pEC₅₀ (pEC₅₀ = −log EC₅₀), whereas maximal obtained relaxation is expressed as a percentage of the precontraction produced by phenylephrine. Each result represents the mean ± SEM (𝑛=4−7).

Pharmacological intervention	pEC50±SEM	Max (%) ± SEM	Pharmacological intervention	pEC50±SEM	Max (%) ± SEM
Denudation (−)	5.91±0.17	102.56±2.56	TEA (−)	6.05±0.18	96.34±0.97
Denudation (+)	4.79±0.38^∗	54.01±2.22^∗	TEA (+)	6.30±0.18	85.50±13.30
DPCPX (−)	5.99±0.27	96.66±5.89	Apamin (−)	5.90±0.19	96.97±3.03
DPCPX (+)	5.88±0.23	89.94±7.62	Apamin (+)	5.47±0.25^∗	91.67±8.33
SCH 58261 (−)	5.71±0.42	97.9±2.09	Glibenclamide (−)	5.84±0.45	101.92±1.92
SCH 58261 (+)	5.46±0.12^∗	56.35±1.84^∗	Glibenclamide(+)	5.76±0.26	89.28±6.83
L-NOARG (−)	6.03±0.25	114.42±8.11	Ba^++ (−)	6.13±0.42	99.98±0.49
L-NOARG (+)	5.51±0.35^∗	78.81±4.62^∗	Ba^++ (+)	6.01±0.38	95.32±3.94
Indomethacin (−)	5.82±0.26	109.37±4.13	Ouabain (−)	6.09±0.26	100.49±1.12
Indomethacin (+)	5.96±0.24	72.25±5.62^∗	Ouabain (+)	6.12±0.28	104.32±2.18
High K^+ (−)	5.92±0.39	97.94±1.09
High K^+ (+)	4.70±0.04^∗	18.76±3.13^∗

^∗𝑃<0.05 compared to the respective control (paired Student’s t-test).