About this Journal Submit a Manuscript Table of Contents
The Scientific World Journal
Volume 2012 (2012), Article ID 168953, 7 pages
http://dx.doi.org/10.1100/2012/168953
Review Article

Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration

1Departamento de Medicina Interna, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, Mexico
2Departamento de Fisiologia, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, Mexico

Received 2 June 2012; Accepted 10 August 2012

Academic Editors: N. L. Banik, F. J. Carod-Artal, and I. Fischer

Copyright © 2012 Carlos Rodrigo Camara-Lemarroy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response. Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration. The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level. In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.