Table 1: Clinically approved modulators of arachidonic acid derivatives.

Drug classCOX inhibitorsEicosanoid analoguesLOX inhibitors
and leukotriene antagonists
Phospholipase inhibitors

ExamplesNSAIDS
Selective COX-2 inhibitors (celecoxib)
Misoprostol (PGE1)
Latanoprost (F2α)
Unoprostone (F2α)
Travoprost (F2α)
Iloprost (PGI2)
Epoprostenol (PGI2)
Zileuton
Zafirlukast
Montelukast
Quinacrine
Mepacrine
Chloroquine

Clinical applicationsAnalgesic
Anti-inflammatory
Pulmonary hypertension (iloprost, epoprostenol)
Glaucoma (latanoprots, unoprostone)
Asthma, allergic rhinitis, urticariaAntiprotozoal
Antirheumatic
Antimalarial

Routes of administrationOral, parenteralInhaled, parenteral, topicalOralOral

NotesZafirlukast and Montelukast are cysteinyl leukotriene receptor CysLT1 antagonists

NSAID: nonsteroidal anti-inflammatory drugs; PGI: prostacyclin.