Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration

Table 1

Clinically approved modulators of arachidonic acid derivatives.

Drug class	COX inhibitors	Eicosanoid analogues	LOX inhibitors; and leukotriene antagonists	Phospholipase inhibitors
Examples	NSAIDS; Selective COX-2 inhibitors (celecoxib)	Misoprostol (PGE1); Latanoprost (F2α); Unoprostone (F2α); Travoprost (F2α); Iloprost (PGI2); Epoprostenol (PGI2)	Zileuton; Zafirlukast; Montelukast	Quinacrine; Mepacrine; Chloroquine
Clinical applications	Analgesic; Anti-inflammatory	Pulmonary hypertension (iloprost, epoprostenol); Glaucoma (latanoprots, unoprostone)	Asthma, allergic rhinitis, urticaria	Antiprotozoal; Antirheumatic; Antimalarial
Routes of administration	Oral, parenteral	Inhaled, parenteral, topical	Oral	Oral
Notes			Zafirlukast and Montelukast are cysteinyl leukotriene receptor CysLT1 antagonists

NSAID: nonsteroidal anti-inflammatory drugs; PGI: prostacyclin.