Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process

Table 3

Experimental plan for the first set of experiments.

No. exp.	X1	X2 (%)	X3 (^∘C)	X4 (m^3/h)	X5 (m^3/h)	X6 (g/min)	X7 (bar)
1	Anhydrous lactose	5	55	30	20	10	1.0/0.5
2	Microcrystalline cellulose	5	55	20	30	5	1.0/0.5
3	Microcrystalline cellulose	10	55	20	20	10	0.5/0.25
4	Anhydrous lactose	10	65	20	20	5	1.0/0.5
5	Microcrystalline cellulose	5	65	30	20	5	0.5/0.25
6	Anhydrous lactose	10	55	30	30	5	0.5/0.25
7	Anhydrous lactose	5	65	20	30	10	0.5/0.25
8	Microcrystalline cellulose	10	65	30	30	10	1.0/0.5

X1: type of diluent.
X2: binder (polyethylene-oxide) concentration (%).
X3: temperature during mixing and granulation (^∘C).
X4: air flow rate during mixing (m³/h).
X5: air flow rate during drying (m³/h).
X6: spray rate (g/min).
X7: atomization pressure (bar).