Research Article
Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
Table 5
Granules characterization.
| | | Y1 | | | Y2 | Y3 | Y4 | Y5 | Y6 | Y7 | | < 180 | 180 < < 315 | 315 < < 500 | > 500 |
| 1 | 52.82 | 39.75 | 7.38 | 0.05 | 7.28 ± 0.6 | 0.625 | 0.750 | 1.20 | 16.67 | 1.4 | 2 | 97.84 | 1.86 | 0.30 | 0.00 | 2.90 ± 0.2 | 0.385 | 0.517 | 1.34 | 25.53 | 3.9 | 3 | 74.31 | 10.28 | 6.44 | 8.97 | 0.00 | 0.341 | 0.468 | 1.37 | 27.14 | 10.1 | 4 | 52.73 | 39.57 | 7.64 | 0.06 | 7.54 ± 0.5 | 0.600 | 0.750 | 1.25 | 20.00 | 0.9 | 5 | 97.38 | 2.22 | 0.40 | 0.00 | 2.50 ± 0.2 | 0.366 | 0.517 | 1.41 | 29.21 | 3.2 | 6 | 35.14 | 47.97 | 16.64 | 0.25 | 6.02 ± 0.4 | 0.555 | 0.682 | 1.23 | 18.62 | 1.0 | 7 | 17.72 | 48.04 | 33.47 | 0.78 | 6.55 ± 0.4 | 0.469 | 0.600 | 1.28 | 21.83 | 3.0 | 8 | 93.39 | 5.79 | 0.83 | 0.00 | 2.83 ± 0.2 | 0.395 | 0.536 | 1.36 | 26.31 | 3.2 |
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Y1: granules size distribution (%). Y2: flowability (g/s). Y3: bulk density (g/mL). Y4: tapped density (g/mL). Y5: Hausner’s ratio. Y6: Carr’s index (%). Y7: moisture content (%).
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