Research Article

Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process

Table 6

Analysis of inf luence formulation and process factors on granules properties.

Granules size distributionFlowabilityBulk densityTapped densityHausner ratioCarr’s indexMoisture content
<180180–315315–500>500

Type of diluent (β1)25.5638−19.3975−7.1450.9788−2.84−0.095−0.091250.0653.91631.7625
Concentration of PEO (β2)−1.27371.4675−1.251.05625−0.3550.005250.00525−0.0025−0.15630.4625
Temperature during mixing and granulation (β3)0.1388−0.531.4475−1.05380.4025−0.0075−0.001250.021.1588−0.7625
Air flow rate during mixing (β4)4.5163−0.50252.825−1.18880.2050.01750.01875−0.005−0.4888−1.1375
Air flow rate during drying (β5)−4.14371.483.6725−1.00630.1225−0.0175−0.01875−0.0025−0.0937−0.0563
Spray rate (β6)−5.60621.53−2.89251.18630.2875−0.01−0.01375−0.0025−0.17381.0875
Atomization pressure (β7)9.0288−2.6925−5.1−1.23630.6850.03250.03625−0.0175−1.0513−0.9875