Research Article
Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
Table 6
Analysis of inf luence formulation and process factors on granules properties.
| | Granules size distribution | Flowability | Bulk density | Tapped density | Hausner ratio | Carr’s index | Moisture content | | <180 | 180–315 | 315–500 | >500 |
| Type of diluent (β1) | 25.5638 | −19.3975 | −7.145 | 0.9788 | −2.84 | −0.095 | −0.09125 | 0.065 | 3.9163 | 1.7625 | Concentration of PEO (β2) | −1.2737 | 1.4675 | −1.25 | 1.05625 | −0.355 | 0.00525 | 0.00525 | −0.0025 | −0.1563 | 0.4625 | Temperature during mixing and granulation (β3) | 0.1388 | −0.53 | 1.4475 | −1.0538 | 0.4025 | −0.0075 | −0.00125 | 0.02 | 1.1588 | −0.7625 | Air flow rate during mixing (β4) | 4.5163 | −0.5025 | 2.825 | −1.1888 | 0.205 | 0.0175 | 0.01875 | −0.005 | −0.4888 | −1.1375 | Air flow rate during drying (β5) | −4.1437 | 1.48 | 3.6725 | −1.0063 | 0.1225 | −0.0175 | −0.01875 | −0.0025 | −0.0937 | −0.0563 | Spray rate (β6) | −5.6062 | 1.53 | −2.8925 | 1.1863 | 0.2875 | −0.01 | −0.01375 | −0.0025 | −0.1738 | 1.0875 | Atomization pressure (β7) | 9.0288 | −2.6925 | −5.1 | −1.2363 | 0.685 | 0.0325 | 0.03625 | −0.0175 | −1.0513 | −0.9875 |
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