Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process

Table 8

The percentage of paracetamol released from tablets in different time interval during 3 hours.

	Compression force 3.5 kN			Compression force 3.75 kN			Compression force 4 kN
Time (min)	A.P. 0.5 bar	A.P. 0.75 bar	A.P. 1 bar	A.P. 0.5 bar	A.P. 0.75 bar	A.P. 1 bar	A.P. 0.5 bar	A.P. 0.75 bar	A.P. 1 bar
5	67.21 ± 1.94	75.47 ± 3.52	5.81 ± 0.93	76.35 ± 5.18	60.06 ± 9.26	7.61 ± 1.96	47.48 ± 4.23	38.74 ± 1.66	5.37 ± 0.15
10	75.05 ± 2.01	78.91 ± 6.75	11.04 ± 3.19	78.77 ± 4.39	67.20 ± 4.42	12.35 ± 2.87	60.83 ± 5.01	38.71 ± 5.20	8.91 ± 0.11
20	78.83 ± 0.23	81.68 ± 3.82	22.11 ± 8.94	82.39 ± 11.27	70.67 ± 4.53	20.67 ± 6.97	80.68 ± 7.25	45.16 ± 13.08	14.74 ± 0.34
30	79.70 ± 5.90	83.30 ± 3.28	28.13 ± 6.86	76.92 ± 3.57	66.91 ± 5.32	21.81 ± 9.07	80.59 ± 6.05	54.54 ± 16.07	18.12 ± 1.88
45	83.25 ± 1.21	87.34 ± 3.35	34.62 ± 11.67	79.67 ± 2.69	74.96 ± 2.56	30.61 ± 13.00	87.18 ± 2.35	69.79 ± 15.05	22.41 ± 1.45
60	85.87 ± 1.22	90.77 ± 1.46	39.80 ± 11.24	84.21 ± 4.40	73.26 ± 7.55	36.18 ± 10.72	85.20 ± 3.84	69.93 ± 14.56	29.03 ± 1.50
90	88.50 ± 1.96	93.93 ± 2.02	50.65 ± 12.73	80.43 ± 11.71	78.09 ± 6.81	44.98 ± 12.02	79.69 ± 5.56	75.31 ± 10.91	41.61 ± 1.21
120	93.75 ± 0.55	96.35 ± 0.02	57.85 ± 12.54	77.99 ± 2.56	85.56 ± 8.07	51.94 ± 12.02	84.69 ± 9.95	75.68 ± 10.67	51.22 ± 0.19
150	96.46 ± 2.53	97.46 ± 3.08	69.80 ± 12.22	78.73 ± 4.96	80.51 ± 3.10	58.44 ± 10.66	84.75 ± 4.89	77.31 ± 7.31	59.24 ± 0.88
180	97.00 ± 1.88	98.00 ± 2.95	62.25 ± 8.66	83.49 ± 8.60	79.33 ± 9.33	62.87 ± 10.00	86.19 ± 6.33	79.86 ± 7.61	64.89 ± 1.71

A.P.: atomization pressure.