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The Scientific World Journal
Volume 2012 (2012), Article ID 194845, 7 pages
http://dx.doi.org/10.1100/2012/194845
Clinical Study

The c.1460C>T Polymorphism of MAO-A Is Associated with the Risk of Depression in Postmenopausal Women

1Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Ul. Polna 33, 60-535 Poznan, Poland
2Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Ul. Szpitalna 27/33, 60-572 Poznan, Poland
3Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Ul. Święcickiego 6, 60-781 Poznan, Poland

Received 9 November 2011; Accepted 1 December 2011

Academic Editors: S. Mastana and J. H. Zhao

Copyright © 2012 R. Słopień et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of the study was an evaluation of possible relationships between polymorphisms of serotoninergic system genes and the risk of depression in postmenopausal women. Methods. We studied 332 women admitted to our department because of climacteric symptoms. The study group included 113 women with a diagnosis of depressive disorder according to the Hamilton rating scale for depression; the controls consisted of 219 women without depression. Serum 17β-estradiol concentrations were evaluated using radioimmunoassay, while polymorphisms in serotoninergic system genes: serotonin receptors 2A (HTR2A), 1B (HTR1B), and 2C (HTR2C); tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), and monoamine oxidase A (MAO-A) were evaluated using polymerase chain reaction-restriction. Results. We found that the 1460T allele of MAO-A c.1460C>T (SNP 1137070) appeared with a significantly higher frequency in depressed female patients than in the control group ( ๐‘ƒ = 0 . 0 1 1 ) and the combined c.1460CT + TT genotypes were associated with a higher risk of depression ( ๐‘ƒ = 0 . 0 1 9 8 ). Patients with the 1460TT genotype had a significantly higher 17β-estradiol concentration than patients with the 1460CT genotype ( ๐‘ƒ = 0 . 0 0 6 5 ) and 1460CC genotype ( ๐‘ƒ = 0 . 0 0 1 8 ). Conclusions. We concluded that depression in postmenopausal women is closely related to the genetic contribution of MAO-A.