Table 1: The genotype distribution between postmenopausal women with ( 𝑤 ) and without ( 𝑤 / 𝑜 ) depression.

Polymorphism 𝑛 Genotype and allele distribution absolute number (frequency) Allele 𝑃 Value Genotype
Odds ratio (95% CI); 𝑃 Value

CCCTTTCT
5HTR2A c. 102C>T (SNP 6313)w depression50441914482 𝑃 = 0 . 7 3 5 0.769 (0.485–1.219)a; 𝑃 = 0 . 2 6 3 4 b
Total 113(0.44)(0.39)(0.17)(0.64)(0.36)
w/o depression8310729273165
Total 219(0.38)(0.49)(0.13)(0.62)(0.38)

GGGC 𝐂 𝐂 GC
5HTR1B c.861G>C (SNP 6296)w depression62447 168 58 𝑃 = 0 . 6 3 5 1.094 (0.693–1.728)a; 𝑃 = 0 . 7 0 0 b
Total 113(0.55)(0.39)(0.06)(0.74)(0.26)
w/o depression1258311333 105
Total 219(0.57)(0.38)(0.05)(0.76)(0.24) )

GGGC 𝐂 𝐂 GC0.996 (0.610–1.628)a; 𝑃 = 0 . 9 8 9 b
5HTR2C c. 68G>C (SNP 6318)w depression7830518640 𝑃 = 1 . 0 0 0
Total 113(0.69)(0.27)(0.04)(0.82)(0.18)
w/o depression151571135979
Total 219(0.69)(0.26)(0.05)(0.82)(0.18) )

CCCTTTCT1.772 (1.112–2.825)a; 𝑃 = 0 . 0 1 9 8 *b
MAO-A c.1460C>T (SNP 1137070)w depression415616 138 88 𝑃 = 0 . 0 1 1 *
Total 113(0.36)(0.50)(0.14)(0.61)(0.39)
w/o depression1109118311127
Total 219(0.50)(0.42)(0.08)(0.71)(0.29) )

CCCAAACA
TPH1 218C>A (SNP 1800532)w depression444920 137 89 𝑃 = 0 . 8 0 1 1.014 (0.637–1.615)a; 𝑃 = 0 . 9 5 3 3 b
Total 113(0.39)(0.43)(0.18)(0.61)(0.39)
w/o depression869934271167
Total 219(0.39)(0.45)(0.16)(0.62)(0.38) )

GGGAAAG A
TPH2 c.1077G>A (SNP 7305115)w depression455117 141 85 𝑃 = 0 . 7 3 7 0.870 (0.546–1.386)a; 𝑃 = 0 . 5 5 7 3 b
Total 113(0.40)(0.45)(0.15)(0.62)(0.38)
w/o depression8010633 266 172
Total 219(0.37)(0.48)(0.15)(0.61)(0.39)

The women’s groups were classified based on the severity of depression assessed by the Hamilton rating scale for depression: w/o depression (0–7), mild depression (8–17), and moderate depression (18–25). The 113 women with depression included 82 women with mild depression and 31 women with moderate depression.
aThe Odds Ratio was calculated for patients homozygous or heterozygous carrying risk allele vs. homozygous.
bFisher exact test was used for comparison of patients with depression versus patients without depression.