Genomic Profiling of a Human Leukemic Monocytic Cell-Line (THP-1) Exposed to Alpha Particle Radiation

Table 5

Canonical functions and networks of dose-responsive genes that were differentially expressed 24 h after irradiation

Category	Score	𝑃 value
Networks
Carbohydrate Metabolism, Lipid; Metabolism, Small Molecule Biochemistry	21	N/A
Diseases and Disorders
Genetic Disorder	N/A	4.45𝐸−02
Inflammatory Response	N/A	3.85𝐸−02
Respiratory Disease	N/A	4.40𝐸−02
Molecular and Cellular Functions
Cell-To-Cell Signalling and Interaction	N/A	4.60𝐸−02
Cellular Development	N/A	4.80𝐸−02
Cellular Growth and Proliferation	N/A	3.66𝐸−02
Physiological System Development and Function
Tissue Development	N/A	4.25𝐸−02
Haematological System Development; and Function	N/A	4.80𝐸−02
Immune Cell Trafficking	N/A	4.60𝐸−02
Top Canonical Pathways
MIF Regulation of Innate Immunity	N/A	2.05𝐸−02
Toll-like Receptor Signalling	N/A	2.50𝐸−02