Genomic Profiling of a Human Leukemic Monocytic Cell-Line (THP-1) Exposed to Alpha Particle Radiation

Table 6

Canonical Functions and networks associated with the dose responsive genes that were differentially expressed 72 h after irradiation.

Category	Score	𝑃 value
Networks
Lipid Metabolism, Molecular; Transport, Small Molecule; Biochemistry	36	N/A
Carbohydrate Metabolism,; Cell-To-Cell Signalling and; Interaction, Cell Death	14	N/A
Developmental Disorder,; Organism Injury and Abnormalities,; Infectious Disease	8	N/A
Diseases and Disorders
Cancer	N/A	3.39𝐸−03
Haematological Disease	N/A	3.39𝐸−03
Genetic Disorder	N/A	3.39𝐸−03
Inflammatory Response	N/A	3.39𝐸−03
Respiratory Disease	N/A	2.38𝐸−03
Molecular and Cellular Functions
Lipid Metabolism	N/A	3.39𝐸−03
Molecular Transport	N/A	3.39𝐸−03
Small Molecule Biochemistry	N/A	3.39𝐸−03
Cell Death	N/A	3.39𝐸−03
Cellular Movement	N/A	3.39𝐸−03
Physiological System Development and Function
Haematological System; Development and Function	N/A	3.39𝐸−03
Immune Cell Trafficking	N/A	3.28𝐸−03
Lymphoid Tissue Structure and; Development	N/A	3.33𝐸−03
Tissue Development	N/A	3.39𝐸−03
Top Canonical Pathways
IL-6 Signalling	N/A	1.09𝐸−02
p53 Signalling	N/A	1.14𝐸−02
Airway Pathology in Chronic; Obstructive Pulmonary Disease	N/A	1.35𝐸−02