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Figure 1: Mouse models of Down syndrome. Hsa21 (in blue) and the syntenic mouse chromosomes (Mmu 16, orange, Mmu 17, purple, Mmu10, green). The trisomic regions of several of the well-established mouse models of DS, the Tc1 mouse, Ts65Dn, Ts1Cje, and Dp(10)1Yey/+, Dp(16)1Yey/+, Dp(17)1Yey/+ are aligned to the corresponding parts of the human and mouse genome.