Review Article
Mouse Models of Aneuploidy
Table 1
Examples of mouse models of segmental aneuploidies.
| Human syndrome | Associated genetic change | Aneuploid mouse models |
| Angelman syndrome | deletion of maternal 15q11–13 | PatDp [37] | MatDf(Ube3a-Gabrb3) [38] | Prader-Willi syndrome | deletion of paternal 15q11–13 | MatDp [37] | Autism risk factor | Duplication 15q11–13 | matDp; pat Dp [57] | Smith-Magenis syndrome | deletion of 17p11/17p11.2 | Df(11)17 [58] | Df(11)17-1; Df(11)17-2; Df(11)17-3 [59] | Potocki-Lupski syndrome | duplication of 17p11/17p11.2 | Dp(11)17 [58] | DiGeorge syndrome | deletion of 22q11.2 | Df1 [44] | Idd-Ctp [45] | Idd-Arvcf [46] | Df2; Df3; Df4; Df5 [60] | Williams-Beuren | deletion of 7q11 | PD and DD [53] | — | deletion/duplication of 17q21 | Df11[
1] and Dp11[ 1] [35] |
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