Mouse Models of Aneuploidy : Table 1

Table 1: Examples of mouse models of segmental aneuploidies.


Human syndrome	Associated genetic change	Aneuploid mouse models

Angelman syndrome	deletion of maternal 15q11–13	PatDp [37]
Angelman syndrome	deletion of maternal 15q11–13	MatDf(Ube3a-Gabrb3) [38]
Prader-Willi syndrome	deletion of paternal 15q11–13	MatDp [37]
Autism risk factor	Duplication 15q11–13	matDp; pat Dp [57]
Smith-Magenis syndrome	deletion of 17p11/17p11.2	Df(11)17 [58]
Smith-Magenis syndrome	deletion of 17p11/17p11.2	Df(11)17-1; Df(11)17-2; Df(11)17-3 [59]
Potocki-Lupski syndrome	duplication of 17p11/17p11.2	Dp(11)17 [58]
DiGeorge syndrome	deletion of 22q11.2	Df1 [44]
		Idd-Ctp [45]
		Idd-Arvcf [46]
		Df2; Df3; Df4; Df5 [60]
Williams-Beuren	deletion of 7q11	PD and DD [53]
—	deletion/duplication of 17q21	Df11[ 1] and Dp11[ 1] [35]