The Scientific World Journal

Clinical Study

Visualization of Chronic Myocardial Infarction Using the Intravascular Contrast Agent MS-325 (Gadofosveset) in Patients

Figure 3

Contrast between enhanced area and normal myocardium increased from 𝑡 1 to 𝑡 3 as enhanced segments showed increasing signal intensities and normal myocardium is assumed to be effectively nullified using the correct inversion prepulse (look locker approach). As blood pool consistently showed the highest signal intensity over the time, blood pool-enhanced area contrast decreased from 𝑡 1 to 𝑡 2 and 𝑡 3 due to increasing SI in the enhanced area and nearly constant SI of the blood pool. The dotted line ( ∗ ) shows data for the extracellular CA Gd-DTPA extracted from a previous study [22]. Using Gd-DTPA (0.2 mmol/kg body weight), the contrast between enhanced area and normal myocardium increased continuously 4 minutes ( 𝑡 1 ) and 26 minutes ( 𝑡 2 ) after CA administration. Contrast between enhanced area and blood pool decreased from 𝑡 1 to 𝑡 2 (prepulse delay 275 ms, TE 3.6 ms, TR 8 ms, flip angle 15°).
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