|
| Study | Country | Population | Intervention doses | Assessed outcomes |
|
(mg) | (UI) |
|
| Han and Zhou 1994 [22] | China | 100 women with low/moderate risk of preeclampsia. Gestational age at entry not informed | Selenium: 0.1 | | Preeclampsia, side effects |
| Chappell 1999 et al. [23] | UK | 283 women with low/moderate and high risk of preeclampsia with gestational age between 16 and 22 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, preterm birth <37 weeks, small for gestational age <10th percentile, baby death, miscarriage |
| Sharma 2003 et al. [24] | India | 251 primigravidae with low/moderate risk of preeclampsia between 16 and 20 weeks of gestation | Lycopene: 4 | | Preeclampsia, small for gestational age <10th percentile |
| Steyn 2003 et al. [25] | South Africa | 200 women with low/moderate risk of preeclampsia with gestational age under 26 weeks | Vitamin C: 500 | | Preeclampsia, preterm birth <37 weeks, baby death, miscarriage, neonatal death |
| Beazley 2005 et al. [26] | USA | 109 women with low/moderate and high risk of preeclampsia with gestational age between 14 and 20 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <10th percentile |
| Poston 2006 et al. [27] | UK and Holland | 2395 women with low/moderate and high risk of preeclampsia with gestational age between 14 and 21 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <5th and <10th percentile, baby death, miscarriage, neonatal death |
| Rumbold 2006 et al. [28] | Australia | 1877 nulliparous women with low/moderate risk of preeclampsia between 14 and 21 weeks of gestation | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, small for gestational age <10th and 3rd percentile, preterm birth <37 weeks, baby death, miscarriage, neonatal death, adverse effects |
| Rumiris 2006 et al. [29] | Indonesia | 60 women with low/moderate and high risk of preeclampsia with gestational age between 8 and 12 weeks | Vitamin B-6: 2.2; vitamin B-12: 0.0022; vitamin C: 200; folic acid: 0.4; n-acetylcysteine: 200; copper: 2; zinc: 15; manganese: 0.5; iron: 30; calcium: 800; selenium: 0.1 | Vitamin A: 1000; vitamin E: 400 | Preeclampsia, preterm birth <37 weeks, miscarriage |
| Spinnato 2007 et al. [30] | Brazil | 707 women with high risk of preeclampsia between 12 and 19 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <10th percentile, baby death, stillborn/miscarriage, neonatal death, adverse effects |
| Banerjee 2009 et al. [31] | India | 159 primigravidae with low/moderate risk of preeclampsia between 12 and 20 weeks of gestation | Lycopene: 2 | | Preeclampsia, severe preeclampsia, preterm birth, baby death, adverse effects |
| Villar 2009 et al. [32] | India, Peru, South Africa, Vietnam | 1365 women with low/moderate and high risk of preeclampsia with gestational age between 14 and 22 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <10th percentile, baby death |
| McCance 2010 et al. [33] | Ireland, Scotland, England | 762 women with high risk of preeclampsia with gestational age between 8 and 22 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, preterm birth <37 weeks, neonatal death |
| Roberts 2010 et al. [34] | USA | 9969 women with low/moderate risk of preeclampsia with gestational age between 9 and 16/6 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <3rd percentile, baby death, miscarriage, neonatal death; side effects |
| Xu 2010 et al. [35] | Canada and Mexico | 2363 women with low/moderate and high risk of preeclampsia with gestational age between 12 and 18 weeks | Vitamin C: 1000 | Vitamin E: 400 | Preeclampsia, severe preeclampsia, preterm birth <37 weeks, small for gestational age <10th and <5th percentile, baby death, miscarriage/stillbirth, neonatal death. |
| Vadillo-Ortega 2011 et al. [36] | Mexico | 444 women with low/moderate and high risk of preeclampsia with gestational age between 14 and 32 weeks | L-arginine: 3300 vitamin C: 250; niacin: 25; vitamin B-6: 2; vitamin B-12: 0.0048; folate: 0.2 | Vitamin E: 200 | Preeclampsia, preterm birth and neonatal death |
|
