Table 5: The IC50 values of the 7-hydroxyflavanone (1) and the biotransformation products.

SubstrateProductIC50* (±SD) [μM]

7-Hydroxyflavanone (1)9.44 (±0.06)
3′,4′-Dihydroxy-7-methoxyflavanone (3)6.70 (±0.07)
2,4-trans-5,7-Dihydroxyflavan-4-ol (5)7.07 (±0.05)
7-Hydroxyflavone (6)8.80 (±0.05)
2,4-cis-7-Hydroxyflavan-4-ol (4)9.17 (±0.03)
7-Methoxyflavanone (2)9.50 (±0.07)

*Mean values of IC50 calculated as an average of at least three measurements.