The Design of New Adjuvants for Mucosal Immunity to Neisseria meningitidis B in Nasally Primed Neonatal Mice for Adult Immune Response
Figure 2
Antigen-specific IgG, IgM, and IgA antibody responses in mice sera after i.n. immunization with native OMPs of N. meningitidis determined by ELISA at 28 days with Stx1, Stx2, or CT as adjuvants. Results are shown as mean titers and error bars indicate standard deviations from the mean. (a) Sera pooled from nine mice immunized with OMPs and stx1; (b) sera pooled from eight mice immunized with OMPs and stx2; (c) sera pooled from ten mice immunized with OMPs and CT. (1) IgG, IgM, and IGA of normal mice; (2) IgG; (3) IgM; (4) IgA. Each scale bar represents the mean ± SE of nine to ten mice per group in an experiment representative of two separate experiments. (a) OMPs and Stx1- IgG, IgM, and IgA containing formulations versus normal sera (); (b) OMPs and Stx2 IgG, IgM, and IgA containing formulations versus normal sera (); (c) OMPs and CT IgG, IgM, and IgA containing formulations versus normal sera ().
