The Design of New Adjuvants for Mucosal Immunity to Neisseria meningitidis B in Nasally Primed Neonatal Mice for Adult Immune Response
Figure 3
Antigen-specific IgG, IgM, and IgA antibody responses in serum stimulated after i.n./i.m. immunization with native OMPs of N. meningitidis at 42 days, 7 days post the i.m prime-boost, in the presence of stx1, stx2, or CT as adjuvants. (b) Sera pooled from nine mice immunized with OMPs and stx1; (a) sera pooled from eight mice immunized with OMPs and stx2; (c) sera pooled from ten mice immunized with OMPs and CT. (1) IgG, IgM, and IgA of normal mice; (2) IgG; (3) IgM; (4) IgA. Each scale bar represents the mean ± SE of nine to ten mice per group in an experiment representative of two separate experiments. (a) OMPs and stx1- IgG, IgM, and IgA containing formulations versus normal sera (), (b) OMPs and stx2 IgG, IgM, and IgA containing formulations versus normal sera (); (c) OMPs and CT IgG, IgM, and IgA containing formulations versus normal sera ().
