The Design of New Adjuvants for Mucosal Immunity to Neisseria meningitidis B in Nasally Primed Neonatal Mice for Adult Immune Response
Figure 4
Concentration of specific anti-OMPs IgA in saliva and vaginal washes of adult mice immunized i.n./i.m. at 42 days, 7 days post the i.m. prime-boost. (a) IgA saliva. (1) IgA saliva antibodies in normal mice; (2) IgA saliva antibodies pooled from nine mice immunized with OMPs and Stx1; (3) IgA saliva antibodies pooled from eight mice immunized with OMPs and Stx2; (4) IgA saliva antibodies pooled from ten mice immunized with OMPs and CT (b) IgA of vaginal washes. (1) IgA vaginal washes antibodies in normal mice; (2) IgA vaginal washes antibodies pooled from nine mice immunized with OMPs and Stx1; (3) IgA vaginal washes antibodies pooled from eight mice immunized with OMPs and Stx2; (4) IgA vaginal washes antibodies pooled from ten mice immunized with OMPs and CT. Each scale bar represents the mean ± SE of mice per group in an experiment representative of two separate experiments. (a) OMPs and stx1 IgA containing formulations saliva versus vaginal washes (). (b) OMPs and stx2 IgA containing formulations saliva versus vaginal washes (). (c) OMPs and CT IgA containing formulations salivaversus vaginal washes ().
