The Design of New Adjuvants for Mucosal Immunity to Neisseria meningitidis B in Nasally Primed Neonatal Mice for Adult Immune Response
Figure 5
Level of IgG1, IgG2a, and IgG2b antibodies present, determined by ELISA, in mouse sera of BALB/c immunized with (a) OMPs of N. meningitidis and stx1 (b) OMPs of N. meningitidis and stx2 and (c) CT, at 42 days, 7 days post the i.m prime-boost. NS: normal mouse sera as control. Each scale bar represents the mean ± SE of nine to ten mice per group per group in an experiment representative of two separate. (a) OMPs and stx1-IgG1, IgG2a, and IgG2b containing formulations versus normal sera (). (b) OMPs and stx2 IgG1, IgG2a, and IgG2b containing formulations versus normal sera (). (c) OMPs and CT IgG1, IgG2a, and IgG2b containing formulations versus normal sera ().
