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The Scientific World Journal
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2012
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Article
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Fig 2
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Review Article
CD8
+
T Cells: GITR Matters
Figure 2
GITR function in antitumoral immunity. Treatment with anti-GITR antibody and GITRL recombinant protein induces activation of CD8
+
cells through upregulation of GITR, release of IFN-
𝛾
and Granzyme B. There is evidence that some tumors express GITRL.