Review Article

CD8+ T Cells: GITR Matters

Figure 2

GITR function in antitumoral immunity. Treatment with anti-GITR antibody and GITRL recombinant protein induces activation of CD8+ cells through upregulation of GITR, release of IFN- 𝛾   and Granzyme B. There is evidence that some tumors express GITRL.
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