Table 1: Candidate gene screen of tumor suppressors.

AlleleNature of allele*Effect

14-3-3zetaP1375P element insertionEnhancer of R
brat1, brat k06028EMS, P element insertionEnhancer of R
Cskc04256P element insertionEnhancer of R
GMR-E2FOverexpresserEnhancer of R
InRE19EMSEnhancer of R
Merlin4loss of functionEnhancer of R
Rab5EY10619P element enhancer upstream,Enhancer of R
Rab5KG05684P element insertionEnhancer of Z (Rab5EY10619 only)
agoEY19092P element insertionEnhancer of Z
dlg1G0276P element insertionEnhancer of Z
GMR-p53OverexpresserEnhancer of Z
Suppressor of R
GMR-reaperOverexpresserEnhancer of Z
Suppressor of R
Ras85e1BEMS missense mutationEnhancer of Z
TorDeltaP, Tork17004Deletion, P element insertionEnhancer of Z
Suppressor of R
awdj2A4P element insertionSuppressor of R
chicoKG00336P element insertionSuppressor of R
GMR-dacapoOverexpresserSuppressor of R
GMR-RbfOverexpresserSuppressor of R
scribj7b3HypomorphSuppressor of R
hyd15EMSSuppressor of Z
l(2)gd1EY04750P element insertionSuppressor of Z
14-3-3epsilons-969antimorphSuppressor of Z

*Information about alleles from FlyBase.
EMS: ethyl methanesulfonate; hypomorph: less protein activity; antimorph: dominant negative protein activity.