A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System
Table 2
EP Line (second chromosome) Genetic Screen: Suppressors (S) and Enhancers (E) of the GMR-R phenotype.
Class
Drosophila gene
Insertion**
Human homolog
Function
S
Beta coatomer protein
Upstream
COPB2
Vesicle transport from Golgi
S
Defective proventriculus
Within
SATB1
Transcription/chromatin organization
S
Paxillin
Within
TGFβ1I1
Signal transduction/adaptor
S
Rack1
Within
GNB2L1
Signal transduction
S
RanBPM
Upstream
RANBP9
Scaffolding/proapoptotic
E*
cdc14
Within/up
CDC14A
Phosphatase/cell cycle/p53
E*
Chip
Upstream
LDB2
LIM domain binding
E*
Female sterile (2) ketel
Upstream
KPNB1
Protein import into nucleus
E*
NAT1
Within/up
EIF4G2
Repressor of translation initiation
E*
Tre oncoprotein related
Upstream
TBC1D3C
Rab GTPase activator
E*
Yippee interacting protein 2
Within/up
ACAA2
Acetyl Coa-acyltransferase
E
14-3-3 zeta
Within
YWHAZ
Signal transduction/insulin pathway
E
Alpha-adaptin
Upstream
AP2A2
Clathrin-coated vesicle transport
E
Bicoid-interacting protein 3
Upstream
MEPCE
Transcription
E
cdGAPr
Within/up
AC108065
GTPase activator
E
CG16896
Upstream
WDR67
Rab GTPase activator
E
Chickadee
Within/up
PFN4
Cytokinesis
E
Genghis khan
Upstream
CDC42BPA
Phosphorylation/actin polymerization
E
Pendulin
Within/up
KPNA
Importin alpha 2/nuclear import
E
RhoGEF2
Within
ARHGF12
Rho GEF/actin dynamics
E
Shroom
Within
SHROOM3
Actin binding
E
TBPH
Upstream
TARDBP
Mrna binding/repressor of transcription
*Indicates a strong enhancer of the GMR-R phenotype.
**Indicates whether the p element insertion, containing the enhancer, lies upstream, where it likely causes overexpression of the gene, or within, where it likely interrupts the coding region. Within/up indicates that the p element lies in the 5′ untranslated region of the gene.
