Table 2: EP Line (second chromosome) Genetic Screen: Suppressors (S) and Enhancers (E) of the GMR-R phenotype.

ClassDrosophila geneInsertion**Human homologFunction

SBeta coatomer proteinUpstreamCOPB2Vesicle transport from Golgi
SDefective proventriculusWithinSATB1Transcription/chromatin organization
SPaxillinWithinTGFβ1I1Signal transduction/adaptor
SRack1WithinGNB2L1Signal transduction
SRanBPMUpstreamRANBP9Scaffolding/proapoptotic
E*cdc14Within/upCDC14APhosphatase/cell cycle/p53
E*ChipUpstreamLDB2LIM domain binding
E*Female sterile (2) ketelUpstreamKPNB1Protein import into nucleus
E*NAT1Within/upEIF4G2Repressor of translation initiation
E*Tre oncoprotein relatedUpstreamTBC1D3CRab GTPase activator
E*Yippee interacting protein 2Within/upACAA2Acetyl Coa-acyltransferase
E14-3-3 zetaWithinYWHAZSignal transduction/insulin pathway
EAlpha-adaptinUpstreamAP2A2Clathrin-coated vesicle transport
EBicoid-interacting protein 3UpstreamMEPCETranscription
EcdGAPrWithin/upAC108065GTPase activator
ECG16896UpstreamWDR67Rab GTPase activator
EChickadeeWithin/upPFN4Cytokinesis
EGenghis khanUpstreamCDC42BPAPhosphorylation/actin polymerization
EPendulinWithin/upKPNAImportin alpha 2/nuclear import
ERhoGEF2WithinARHGF12Rho GEF/actin dynamics
EShroomWithinSHROOM3Actin binding
ETBPHUpstreamTARDBPMrna binding/repressor of transcription

*Indicates a strong enhancer of the GMR-R phenotype.
**Indicates whether the p element insertion, containing the enhancer, lies upstream, where it likely causes overexpression of the gene, or within, where it likely interrupts the coding region. Within/up indicates that the p element lies in the 5′ untranslated region of the gene.